Note: These instructions comply with those formulated by the International
Committee of Medical Journal Editors. For further details, authors should
consult their article: Uniform requirements for manuscripts submitted to
biomedical journals. N Engl J Med 1991, 324:424428.
The Journal of Hypertension publishes papers reporting original clinical
and experimental research which are of a high standard and which contribute
to the advancement of knowledge in the field of hypertension. The Journal
publishes full papers and reviews or editorials (normally by invitation).
Manuscripts submitted to Journal of Hypertension will be accepted
on the understanding that the author must not have previously submitted the
paper to another journal or have published the material elsewhere. Authors
who submit papers to the Journal must document that all persons acknowledged
have seen and approved the mention of their name in the paper.
Manuscripts should be sent to: Professor Alberto Zanchetti, Editor,
Journal of Hypertension, Centro di Fisiologia Clinica e Ipertensione, University
of Milan, Ospedale Maggiore, Via F. Sforza 35, 20122 Milan, Italy. Submissions
should consist of four copies, three of which may be photocopies. Authors
must also supply three copies of all figures and tables. Manuscripts should
be typed on white bond paper. Margins should be not less than 3 cm. Double
spacing should be used throughout the manuscript including the following
sections, each of which should begin on a separate sheet: title page, summary
and keywords, text, acknowledgements, references, individual tables and captions.
Pages should be numbered consecutively, beginning with the title page.
Abbreviations, if used, should be defined on their first appearance in the
text and those not accepted by international bodies should be avoided.
Special Reports should be short descriptions of recent findings on topics
of current importance. Papers submitted as Special Reports will receive
a decision from the Editor within 2 weeks. No written comments or opportunity
for revision will be provided, and accepted papers will be published in
the next issue to press. Papers adjudged unacceptable for publication
in their present form may be resubmitted for full peer review.
Special Reports should consist of no more than 2000 words, have 20 or fewer
references and contain no more than two figures or tables. Authors wishing
for their paper to be considered for this category should indicate so in
their letter of submission.
Summaries of papers with large amounts of information
It is impractical to publish very large amounts of data (e.g. from technical
reports, phase 2 and phase 3 clinical trials, new study protocols, etc.)
in the Journal. In these cases the Editor may ask that only a shortened version
of the paper be published in the Journal. The author should state in this
paper where the full data are available, and may request Rapid Science Ltd
to hold the data in electronic format, for which a small charge will be made.
There will, of course, be no charge for the publication of the summary in
Presentation of papers
All original papers must be arranged in sections under the headings and in
the order indicated below:
The title page should carry the
full title of the paper, consisting of no more than 20 words (only common
abbreviations should be used if absolutely necessary); titles should be clear
and brief, conveying the message of the paper
a brief short title, which will be used as running head (consisting of not
more than 40 characters, including spaces)
all authors’ names: the full first name, middle initial and last name
of each author should appear; if the work is to be attributed to a department
or institution, its full name and location should be included. Persons listed
as authors should be those who substantially contributed to the study’s
conception, design, and performance
the affiliations of all the authors; when authors are affiliated to more
than one institution, their names should be connected using a , b ,
c , etc. These letters should follow the surname but precede the
address; they should be used for all addresses
information about previous presentations of the whole or part of the work
presented in the article
the sources of any support, for all authors, for the work in the form of
grants, equipment, drugs, or any combination of these
a statement on potential conflicts of interest: if authors have financial
interests relevant to the research or constituting a conflict of interest,
these must be stated. If not applicable, state NONE
disclaimers, if any
the name and address of the author responsible for correspondence concerning
the manuscript, and the name and address of the author to whom requests for
reprints should be made. If reprints are not to be made available, a statement
to this effect should be included. The peer-review process as well as publication
will be delayed if you do not provide up to date telephone and fax numbers,
and E-mail address, if available
wordcount: please list full wordcount (including references)
The second page should carry an abstract not exceeding 250 words.
Please list abstract wordcount at the end of the abstract.
(a) Articles containing original data concerning the course, cause, diagnosis,
treatment, prevention or economic analysis of a clinical disorder or an
intervention to improve the quality of health care should include a structured
abstract with the following headings and information:
Objective: State the main question or objective of the study and the
major hypothesis tested, if any.
Design: Describe the design of the study indicating, as appropriate,
use of randomization, blinding, criterion standards for diagnostic tests,
temporal direction (retrospective or prospective), etc.
Setting: Indicate the study setting, including the level of clinical
care (for example, primary or tertiary; private practice or institutional).
Patients, participants: State selection procedures, entry criteria
and numbers of participants entering and finishing the study.
Interventions: Describe the essential features of any interventions
including their method and duration of administration.
Main outcome measure(s): The primary study outcome measures should
be indicated as planned before data collection began. If the hypothesis being
reported was formulated during or after data collection, this fact should
be clearly stated.
Results: Describe measurements that are not evident from the nature
of the main results and indicate any blinding. Absolute values should be
indicated when risk changes or effect sizes are given.
Conclusions: State only those conclusions of the study that are directly
supported by data, along with their clinical application (avoiding
overgeneralization). Equal emphasis must be given to positive and negative
findings of equal scientific merit.
(b) Articles concerning original experimental research should include a
structured abstract with the following headings and information:
Objective(s): State the primary objective of the paper (if appropriate).
Design: State the principal reasoning for the procedures adopted.
Methods: State the procedures used. Results: State the main results
of the study. Numerical data may be included but should be kept to a minimum.
Conclusions: State the conclusions that can be drawn from the data given.
(c) Review articles should include an abstract which, if appropriate, may
be structured with the following headings: Purpose, data identification,
study selection, data extraction, results of data analysis, conclusions.
The abstract should be followed by a list of 310 keywords or short
phrases which will assist the cross-indexing of the article and which will
be published. When possible, the terms used should be from the Medical Subject
Headings list of the Index Medicus.
Full papers of an experimental or observational nature may be usefully divided
into sections headed Introduction, Methods, Results and Discussion, although
reviews may require a different format.
Use of abbreviations should be kept to an absolute minimum; abbreviations
and abbreviated phrases should be written out at first mention followed by
the abbreviation in parentheses. Avoid those not accepted by international
bodies. Use generic names of drugs. When a specific product or item of equipment
is first mentioned, give the manufacturer’s name and the place of manufacture
(city, state, country) in parentheses. Système Internationale (SI)
units should be used where appropriate.
Acknowledgements should be made only to those who have made a substantial
contribution to the study. Authors are responsible for obtaining written
permission from people acknowledged by name in case readers infer their
endorsement of data and conclusions.
References should be numbered consecutively in the order in which they first
appear in the text. They should be assigned arabic numerals which should
be given in brackets, e.g. , not superscript. Cite the reference
number immediately after the author’s name in the text (e.g. Smith et
al.  studied 40 patients not Smith et al. studied 40 patients ).
Any cited in figures and tables should be numbered according to the position
in which the figure or table is first cited in the text.
References should include the names of all authors when six or fewer; when
seven or more, list only the first six names and add et al. References should
also include full title and source information. Journal names should be
abbreviated as in the Index Medicus.
Example I (journal): Peterson HR, Rothschild M, Weinberg CR, Fell
RD, McLeish KR, Pfeifer MA. Body fat and the activity of the autonomic nervous
system. N Engl J Med 1988; 318:10771083.
Example II (book): Folkow B. Autonomic nervous system in hypertension.
In: Swales JD (editor): Textbook of Hypertension. Oxford: Blackwell
Scientific; 1994, pp. 427438.
Personal communications and unpublished work should not feature in the reference
list but should appear in parentheses in the text. Unpublished work accepted
for publication but not yet released should be included in the reference
list with the words ‘in press’ in parentheses beside the name of the journal
concerned. References must be verified by the author(s) against the original
Each table should be typed on a separate sheet in double spacing. Tables
should not be submitted as photographs. Each table MUST have a title and
should be assigned an arabic numeral, e.g. (Table 3). Vertical rules should
not be used. Tables should not duplicate the content of the text.
Each table should consist of at least two columns.
If applicable, table headings should indicate whether the figures used represent
percentages, by (%) after the figure, or units. Columns should always have
Information should be listed in the following order:
abbreviations and symbols should be defined in the order in which they appear
in the table (reading across each line rather than down columns); spell out
ALL abbreviations and symbols used in the table, even if they have
already been listed in previous tables or the text itself when giving
a key, use a comma rather than =, e.g. H, hypertensive NOT
any additional comments should follow the explanation of abbreviations and
keys to the P values should be listed in the following order (note the use
of asterisks for probability): *P < 0.05, **P < 0.01, ***P < 0.001;
asterisks are the only symbols that should be used with P values; DO NOT
use @ or #.
Checklist for data in tables
the data are consistent with those cited in the relevant parts in the text
totals add up correctly
percentages have been calculated correctly
Please see the following page.
If a table or figure have been published before, the authors must obtain
written permission from the copyright holder, which should be submitted with
the material. The request for permission must clearly state that the material
will appear in both print and electronic formats (including Internet and
CD-ROM). Publication of accepted manuscripts whose authors have not obtained
such permission will be delayed.
Units: the Système Internationale (SI)
The Journal of Hypertension employs SI Units (see Quantities, Units, and
Symbols, 2nd edn. London: The Royal Society of Medicine; 1975). All submitted
papers should use this system, which should be departed from only where
long-established clinical usage demands it (e.g. the measurement of blood
pressure in mmHg). Where helpful, other units of measurement may be included
in parentheses. Whenever possible, renin should be expressed in terms of
the International Standard Renin Unit [Bangham et al.: Clin Sci
1975, 48 (suppl):135s159s]. Derived SI units may also be used,
and for basic and derived units prefixes to denote multiples and submultiples
may be used.
Nomenclature for experimental renovascular hypertension
Contributors should follow the Special Report of the Nomenclature Committee
of the Council for High Blood Pressure Research of the American Heart Association
(Page IH, Oparil S, Bohr DF, Tobian L: Nomenclature for experimental
renovascular hypertension. Hypertension 1979, 1:61):
Goldblatt hypertension: One-kidney, one clip hypertension; two-kidney,
one clip hypertension; two-kidney, two clip hypertension.
Page hypertension: One-kidney, one wrapped hypertension; two-kidney,
one wrapped hypertension; two-kidney, two wrapped hypertension.
Grollman hypertension: One-kidney, one figure-8 hypertension; two-kidney,
one figure-8 hypertension; two-kidney, two figure-8 hypertension.
Nomenclature for hypertensive rat strains
Contributors should follow the nomenclature accepted at the Eleventh Meeting
of the International Society of Hypertension in Heidelberg, West Germany,
1986 (Hypertension 1987, 9:110).
Nomenclature for the reninangiotensin system and animal peptides
Contributors should follow the Report of the Joint Nomenclature and
Standardization Committee of the International Society of Hypertension, the
American Heart Association and the World Health Organization (J
Hypertens 1987, 5:507511).
Offprints may be purchased at terms to be made available with proofs. Orders
should be sent when the proofs are returned; orders received after this time
cannot be fulfilled. Editorial communications should be addressed to: The
Publishing Editor, Journal of Hypertension, Rapid Science Ltd, 26
Boundary Row, London SE1 8HN, UK (Tel: 0171 865 0198; Fax: 0171 928 0748).
Business communications (subscriptions, advertising, etc.) should be addressed
to: The Publishing Editor, Journal of Hypertension, Rapid Science Ltd,
26 Boundary Row, London SE1 8HN, UK (Tel: 0171 865 0198; Fax: 0171
Sizes and presentation
Figures should be professionally drawn and photographed; freehand or typewritten
lettering is unacceptable. Artwork should be submitted either as glossy prints
or as high-quality laser prints; dot-matrix printers do not produce artwork
suitable for publication. Line illustrations should be submitted as original
artwork or prints to a width of 82 mm or, when the illustration demands it,
to a width of 176 mm. All illustrations should have a label pasted on the
back bearing the figure number, the title of the paper, the author’s name
and an arrow indicating the top of the figure. Avoid writing directly on
the back of prints. Do not mount illustrations.
Supply halftone illustrations (photographs) as sharp, glossy, black-and-white
prints, preferably to a width of 82 mm. Photomicrographs must have internal
scale markers. If photographs of people are used, their identities must be
obscured or the picture must be accompanied by written permission to use
the photograph. Photographs may be cropped or deleted at the discretion of
Legends for illustrations
All illustrations must have legends. These should be typed using double spacing,
beginning on a separate page, each with an Arabic nubmeral corresponding
to the illustration to which it refers. All abbreviations used in the
illustration must be defined in the legend. Internal scales should be explained,
and staining methods for photomicrographs identified. Keys to symbols should
be given in the legend, and not on the figure itself.
The cost of colour reproduction will be borne by the author. An estimate
will be provided before the illustration is processed.