Simon Litvak, Institut de Biochimie et Genetique Cellulaires-Bordeaux

Taking a unified approach to the topic, this volume is an up-to-date presentation of rapid progress made in the field of the retroviral reverse transcriptase, an enzyme crucial in the replication of retroviruses (pathogen agents that may cause tumors, leukemias and AIDS). Retroviral Reverse Transcriptases describes the structure and function of this enzyme, placing special emphasis on the HIV-1 enzyme. This book also considers the presence of reverse transcriptase in other animal, plant, yeast and bacterial systems, and it devotes attention to the search of specific inhibitors of the retroviral reverse transcriptase (some of which are already used in clinics against pathologies produced by these agents).

Audience: clinical specialists, researchers, medical students and life science predoctoral students in infectious disease, virology, immunology, cell biology, structural biology and biochemistry

Molecular Biology Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.205pp
57 figures, 2 tables
Hardback: 0-412-10381-8: $69.95


Edited by Marek Michalak, University of Alberta

In recent years, it has been discovered that calreticulin, a multifunctional calcium-binding protein, is involved in many aspects of cellular biology. The protein has been described in various locations: endoplasmic reticulum, nuclear envelope, cytoplasmic granules, nucleus, cell surface and even secreted into the blood stream. Calreticulin offers a current, comprehensive introduction to the structure and function of this unique and ubiquitous protein. It outlines the newly discovered functions for calreticulin, including its: * control of calcium homeostasis, * modulation of steroid-sensitive gene expression, * control of viral RNA replication, * modulation of nuclear transport, * role in T lymphocyte activation and cytoxic killing, * chaperone function, * control of adhesion-dependent signaling via integrins, and * possible role in the biology of ticks, in the pathology of autoimmune diseases and in blood function.

Audience: hematologists, virologists, cell biologists and molecular biologists

Molecular Biology Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.230pp
43 figures, 4 tables
Hardback: 0-412-10101-7: $69.95


Molecular Structure to Cellular Function Edited by Barbara A. Seaton, Boston University

Annexins are a family of eukaryotic proteins that have been implicated in a wide range of cellular processes, many involving membranes and cytoskeletal elements. Some annexins have anticoagulant, anti-inflammatory, and/or ion-regulating activities and may play roles in membrane trafficking. The calcium-dependent binding of annexins to membranes has received much attention, and these proteins currently offer a detailed model of membrane binding by proteins. Annexins: Molecular Structure to Cellular Function integrates crystallographic and other high-resolution structural data into issues related to annexin function, while the overall focus is on research with a more cellular emphasis. Taking a broad, multidisciplinary approach, authors present recent data from both structural and functional perspectives in this rapidly growing field.

Audience: clinical specialists and researchers in cell biology, molecular biology and metabolism

Molecular Biology Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.262pp
73 figures, 8 tables
Hardback: 0-412-10261-7: $69.95


Role in vertebrate development, function and adaptation

Edited by Judith Harmony, University of Cincinnati Medical Center

With an emphasis on clinical implications, this book provides an historical perpective on the discovery of the protein clusterin, as well as an up-to-date summary of the properties and potential functions of the protein. Topics include: *clusterin as a lipid transport protein *regulation of complement function *constitutive, developmental and induced expression of clusterin at dynamic bio-interfaces *mechanisms of induction and function of clusterin at sites of cell death *clusterin in the mammalian heart * clusterin in the kidney * the reproductive biology of clusterin and * recent findings on clusterin in the neural tissues

Audience: clinical specialists and researchers in the areas of metabolism, molecular cell biology, immunology, neuroscience, neurology, reproductive biology, endocrinology, physiology, cardiology and vascular biology

Molecular Biology Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.182pp
28 figures
Hardback: 0-412-09921-7: $69.95


Edited by Ernst Heinen, Universite de Liege, Belgium

This book covers different aspects of follicular dendritic cells: *their morphological, phenotypic and functional features * their origin * their relationship to B and T cells *their involvement in pathological conditions. Eleven chapters written by specialized teams address features related to follicular dendritic cells, each taking a unique point of view and covering complementary fields. Authors consider the wealth of new data on lymph follicles in normal and pathological situations, appropriate for fostering new methods of memory cell formation and vaccination, as well as for antiviral treatments. Audience: clinical specialists, researchers and medical students in cell biology, immunology, transplantation and infectious disease

Molecular Biology Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.201pp
42 figures, 8 tables
Hardback: 0-412-10141-6: $69.95


Edited by Larry Fliegel, University of Alberta

This volume concentrates on recent developments in the Na+/H+ Exchanger, particularly advancements in the biochemistry, molecular biology and physiology of the protein. Since the isolation and cloning of the first Na+/H+ Exchanger in 1989, there has been an explosion in the knowledge of isoforms, including cloning and isolation of new isoforms and the gene for the first isoform. The Na+/H+ Exchanger explores cutting-edge information on both the protein and its isoforms; it offers a comparison with other Na+/H+ Exchanger isoforms of non-mammalian species and reviews recent evidence on the important role of the protein in the contractile failure associated with ischemia.

Audience: clinical specialists and researchers in molecular biology, biochemistry and physiology

Molecular Biology Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.297pp
51 figures, 16 tables
Hardback: 0-412-10471-7: $69.95


Emerging roles in vesicle trafficking, signal transduction and metabolic regulation

Vytas A. Bankaitis, University of Alabama at Birmingham; Michelle R. Fry, University of Alabama at Birmingham; Robert T. Cartee, Bradley University and Satoshi Kagiwada, RIKEN

Interest in phospholipid transfer proteins has resurged during the past five years, due to the development of both in vivo and in vitro assays for the fuctional dissection of the physiological roles of individual phospholipid transfer proteins. In particular, the phosphatidylinositol/ phosphatidylcholine transfer proteins are key regulators of secretory pathway function, phospholipid biosynthesis and phospholipid-driven signal transduction pathways.Phospholipid Transfer Proteins provides a general reference on the biochemistry and cell biology of these proteins, as well as an up-to-date account of the exciting developments in phosphatidylinositol/ phosphatidylcholine transfer protein function in cells.

Audience: researchers, residents, medical students and graduate students in signal transduction and metabolism

Molecular Biology Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.163pp
28 figures, 1 table
Hardback: 0-412-10431-8: $69.95


Edited by Jan G.J. van de Winkel, University of Utrecht, Netherlands

Antibodies are crucial to the fine specificity of the immune system. An effective functioning of these molecules requires interaction with immune cells. Receptors for immunoglobulins provide this critical link between the humoral and cellular branches of the immune system. Human IgG Fc Receptors focuses on IgG Fc receptors playing a crucial role in immunity. In recent years, insight into the complexity of these molecules has increased dramatically. Importantly, recent work indicates the extensive heterogeneity within the FcgR family to be relevant to infectious and autoimmune diseases. This comprehensive overview is the first that is dedicated exclusively to human IgG Fc receptors, and it is contributed by experts in the field.

Audience: clinical specialists in signal transduction, cell biology, immunology, reproductive biology and infectious disease

Molecular Biology Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.225pp
40 figures, 9 tables
Hardback: 0-412-10071-1: $69.95


Edited by Gary Peltz, Syntex, Palo Alto, California

This book provides a unique perspective on the rapidly advancing area of leukocyte recruitment in inflammatory disease. Leukocyte Recruitment in Inflammatory Disease indicates how insight into the pathogenetic mechanisms underlying human inflammatory disease have evolved from understanding the processes regulating leukocyte recruitment into inflammed tissues provides a unique systematic examination of factors regulating organ-specific leukocyte recruitment offer a novel perspective in evaluating data obtained from analysis of experimental animal models of inflammation * attempt to determine whether in vivo data validates or indicates a need for changing generally accepted paradigms on the processes regulating leukocyte recruitment into inflammed tissues * analyzes leukocyte recruitment from a biomedical perspective * questions whether our current understanding of this process, along with our technological capabilities, enable the development of clinically useful agents that selectively modulate leukocyte recruitment

Audience: clinical specialists and researchers in cell biology and immunology

Molecular Biology Intelligence Unit series

R. G. Landes Company
March 1996 : 6 x 9 : approx.306pp
24 figures, 23 tables
Hardback: 0-412-10461-X: $69.95


Thomas Zeuthen, Institute of Medical Physiology, University of Copenhagen, Copenhagen

Molecular Methods of Water Transport focuses on how water crosses biological membranes. It describes transport via membrane proteins, both of the channel type and of the cotransport type, as well as transport via the liquid phase. It then combines these pathways into a complete molecular model for cellular water homeostasis. This new concept integrates recent molecluar biological findings with knowledge about transport physiology; it presents a detailed picture of the interactions between protein structure, conformational changes, protein associated water, driving forces and vectorial water fluxes. The molecular model for cellular water homeostasis is applied to a variety of cellular systems: bacteria, mitochondria, mycoplasms, plant cells, fresh water organisms and epithelial systems. This book's unique approach bridges the gap between cellular and molecular biology.

Audience: clinical specialists, residents, medical students, biologists, physiologists, molecular physiologists and plant physiologists

Molecular Biology Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.200pp
51 figures, 6 tables
Hardback: 0-412-10311-7: $69.95


Structure, Function and Biology

Peter Gettins, University of Illinois-Chicago (UIC); Philip A. Patston, (UIC) and Steven T. Olson, (UIC)

The field of serpin research has expanded enormously during the last five years, and it continues to grow, with the discovery of new serpins nearly every month. Because of the structural and mechanistic similarities between serpins, understanding of the behavior of one serpin contributes to an understanding of others. This book is the first to comprehensively examine serpins as a family and to synthesize mechanistic and structural information on related serpins. It is the only available source to include tables of relevant kinetic and structural data. The authors provide critical evaluations of mechanistic aspects of serpins, as well as an up-to-date bibliography of more than 1,000 references to both original literature and focused reviews.

Audience: researchers, medical students and graduate students in molecular biology, metabolism, biochemistry, pharmacology and molecular biophysics

Molecular Biology Intelligence Unit series

R. G. Landes Company
January 1996 : 6 x 9 : approx.215pp
41 figures
Hardback: 0-412-10351-6: $69.95

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