From Pathogenesis to Treatment
Edited by Donald Y. M. Leung, National Jewish Center for Immunology and Respiratory Medicine

This practical and comprehensive text discusses the most recent information available on the clinical characteristics, immunopathogenesis and treatment of atopic dermatitis. It highlights the latest advancements in our understanding of the immunology and pathophysiology of atopic skin, and it provides a detailed review of current and potential approaches to the management of this increasingly common illness. Clinical manifestations of atopic dermatitis are extensively reviewed, as are the roles of food and inhalant allergins and infectious agents. This well-referenced volume offers an integrated approach to the management of atopic dermatitis.

Audience: allergists, dermatologists, clinical specialists, general clinicians, researchers and residents in cell biology, immunology and dermatology

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.234pp
34 figures, 22 tables
Hardback: 0-412-10191-2: $79.95


C.V. Dang, Johns Hopkins University School of Medicine and Linda A. Lee , Johns Hopkins University School of Medicine

Examines the c-Myc protooncogene, which is frequently altered in many human cancers, and its protein product c-Myc. c-Myc's function is vital: it participates in the regulation of both cell proliferation and programmed cell death. Recent discoveries have shed new light on c-Myc and neoplasia, inspiring this book. Comprehensive and timely, c-Myc Function in Neoplasia provides many historical perspectives, and it places information on c-Myc into current conceptual frameworks. References include both original and review articles. The volume begins with brief overviews of signal transduction and neoplastic transformation, followed by a review of the discovery of Myc. Topics include regulation of c-Myc gene expression, c-Myc in human neoplasia, and current observations on c-Myc protein structure, function and its interactions with other proteins. The final chapter overviews genes that appear to be regulated by c-Myc and their role in c-Myc induced neoplastic transformation and apoptosis.

Audience: clinical specialists, researchers, residents and medical students in molecular oncology

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.190pp
34 figures
Hardback: 0-412-10231-5: $79.95


Anne Kelso, Queensland Institute of Medical Research and Andrew Clouston, Department of Pathology, University of Queensland

Transplantation offers proof that cytokines occupy a pivotal position in the initiation, potentiation and regulation of inflammatory processes. This monograph provides an overview of the roles cytokines play in transplantation, from the early recruitment of inflammatory cells into the graft, to the activation or blocking of specific effector cells leading to rejection or graft acceptance. These findings are considered in the broader context of the general cytokine network and its regulation. Cytokines in Transplantation also discusses the advantages and pitfalls of the various methods of cytokine detection. Featuring comprehensive reviews of current knowledge of cytokines in a range of transplantation-related topics, this monograph includes extensive and up-to-date resources.

Audience: clinical specialists and researchers in molecular biology, cell biology, transplantation, immunology and cytokines

Medical Intelligence Unit series

R. G. Landes Company
January 1996 : 6 x 9 : approx.194pp
14 figures, 14 tables
Hardback: 0-412-10361-3: $79.95


Edited by Michael H. Torosian, Division of Surgical Oncology, Department of Surgery, University of Pennsylvania, Pennsylvania

This monograph summarizes the extraordinary explosion of basic science and clinical research that has been conducted on growth hormone, predominantly over the past decade. Topics detailed include: * the genetics of growth hormone expression * the molecular modification of growth hormone resulting in its heterogenous group of active polypetptides * growth hormone-binding proteins and cellular membrane receptors that modify and regulate its activity, and * physiologic factors that control growth hormone secretion. Growth Hormone in Critical Illness is a complete, concise review of all experimental and clinical research on growth hormone.

Audience: clinicians, researchers and residents in molecular and cell biology, immunology, oncology, transplantation, nutrition and metabolism

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.225pp
44 figures, 26 tables
Hardback: 0-412-09971-3: $79.95


Edited by Stanley P.L. Leong, Associate Professor of Surgery, Mount Zion Cancer Center, University of California, San Francisco, California

Taking a progressive approach, this monograph summarizes the principles and practices of immunotherapy of malignant melanoma. The incidence of malignant melanoma is rising approximately every eight years on a global level; when it becomes metastatic, there is no curative treatment available to date, as it is not respectable and does not respond reliably to chemotherapy or radiation therapy. The past decade has witnessed significant strides in the understanding of the immune responses, particularly on a molecular level. Immunotherapy of Malignant Melanoma is a concise summary of the background, rationale and current practice of immunotherapy against melanoma.

Audience: clinical specialists, general clinicians and researchers in oncology and immunology

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.162pp
11 figures, 2 tables
Hardback: 0-412-10491-1: $79.95


Edited by Fionula M. Brennan, Kennedy Institute of Rheumatology, London and Marc Feldman, Kennedy Institute of Rheumatology, London

Cytokines are the powerful local protein mediators that are of major importance in virtually every biological process: immunity, inflammation, cell growth, repair and fibrosis. Proven clinically succesful in haemopoietic growth factors and interferons, cytokines are a vital area of research. Cytokines and Autoimmunity examines cutting-edge information on the involvement of cytokines in autoimmune diseases and aims to promote the rational therapeutic application of this field. One victory is apparant already: this volume defines TNFa as a major proinflammatory cytokine in rheumatoid arthritis, leading to successful clinical trials of anti-TNFa antibody in these patients. These unequivocally (and reproducible) successful trials of an anticytokine therapy suggest that knowledge of cytokine networks in a variety of diseases will lead to future therapeutic successes.

Audience: clinical specialists and researchers in immunology and infectious diseases

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.259pp
37 figures, 20 tables
Hardback: 0-412-10271-4: $79.95


Edited by Claudio Fiocchi, Case Western Reserve University

Few subjects of modern medicine have attracted so much attention as mediators of immunity. These agents, collectively named cytokines, display such potent and broad biological activities that they have been implicated in essentially all aspects of the normal immune response, as well as the immune abberations associated with neoplastic and inflammatory diseases. The pathogenesis of both forms of inflammatory bowel disease--Chron's disease and ulcerative colitis--depends on complex immune abnormalities. The investigation of cytokines has become critical to basic, clinical and therapeutic aspects of these enigmatic entities. Cytokines in Inflammatory Bowel Disease offers clear, concise, state-of-the-art information on the role of various immunoregulatory and pro-inflammatory mediators in Chron's disease and ulcerative colitis. Each cytokine is analyzed in regard to pathogenetic and clinical implications, as well as immunological and molecular in vitro systems. The importance of cytokine research for the development of novel forms of therapy is emphasized.

Audience: clinical specialists, researchers, residents, research fellows and allied health personnel in gastroenterology, immunology, molecular biology, cell biology and cytokines.

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.247pp
39 figures, 21 tables
Hardback: 0-412-10051-7: $79.95


Edited by Pnina Brodt, McGill University

This book provides an up-to-date review of current concepts on the role of cellular adhesion mechanisms in the pathology of cancer, with an emphasis on their involvement in the processes of invasion and metastasis. The volume begins with short reviews of the literature. Contributed by experts in the field, the reviews are intended to familiarize the reader with the literature on the major families of adhesion receptors and proteolytic enzymes, which play a major role in cancer metastasis. This information forms the basis for the second part of the book, a comprehensive review of the role of these mediators in cancer invasion and metastasis. Cell Adhesion and Invasion Mechanisms in Cancer Metastasis incorporates recent studies and current ideas on the activity between adhesion receptors and other mediators of metastasis such as growth factor receptors and proteinases. Contributions emphasize the interdependence of these mediators at the levels of transcriptional regulation and expression.

Audience: clinical specialists and researchers in molecular oncology and adhesion

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.258pp
20 figures, 4 tables
Hardback: 0-412-10151-3: $79.95


Edited by Peter W. T. Pisters, Memorial Sloan-Kettering Cancer Center andMurray F. Brennan, Memorial Sloan-Kettering Cancer Center

Cancer cachexia is a complex syndrome characterized by diminished nutrient intake and progressive tissue depletion manifested clinically as anorexia and weight loss. This book examines the basic research that has addressed the fundamental derangements in host intermediary protein metabolism, and it evaluates current therapeutic approaches to the management of cancer cachexia.

Audience: clinical specialists, surgeons and researchers in oncology, nutrition and metabolism

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.213pp
26 figures, 24 tables
Hardback: 0-412-10031-2: $79.95


Edited Christian Boitard, Hopital Necker, Paris

This volume details the involvement of B cells in autoimmune diseases, through both the production of autoantibodies and their participation in antigen presentation and immune regulation. Autoantibodies function in a variety of ways: * they are used as biological markers of various autoimmune diseases in clinical practice * they are directly responsible for tissue lesions in some autoimmune states * they are used as probes for characterizing autoantigens involved in autoimmunity B cells are central to antigen presentation and immune regulation in the pysiological state. Their dysfunction may directly result in autoimmunity, as evidenced by various experimental models of autoimmunity and some examples of autoimmune diseases in the human. This book considers the relation of B cells to regulatory T cells, as well as regulatory networks that connect B cells, T cells and tissues expressing autoantigens.

Audience: clinical specialists, physicians and researchers in immunology and physiology

Medical Intelligence Unit series

R. G. Landes Company
March 1996 : 6 x 9 : approx.270pp
19 figures, 11 tables
Hardback: 0-412-10171-8: $79.95


F. William Orr, University of Manitoba and Gurmit Singh, McMaster University

Featuring contributions from active investigators with research programs on bone metastasis, this volume summarizes current concepts of the pathophysiology of secondary bone cancer. Bone Metastasis first covers interactions between cancer cells and the unique microenvironment in bone, emphasizing the influence of the latter on cancer cell adhesion and growth. It also discusses the mechanisms of tumor-mediated osteolysis, animal models and implications of the pathophysiology for therapy. This book is the first to focus on the mechanisms and pathophysiology of the disease.

Audience: clinical specialists, researchers, residents and medical students in clinical oncology, hematology, endocrinology and orthopedics

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.207pp
73 figures, 13 tables
Hardback: 0-412-10341-9: $79.95


Edited by Dominique Kaiserlian, Institut Pasteur-Lyon

This volume offers a comprehensive overview of the most recent and innovative data illustrating the importance and the place of intestinal epithelial cells in mucosal immunity. It places special emphasis on their function as antigen presenting cells, and as such, potentially involved in the regulation of the local immune response to both self and exogenous antigens. Antigen Presentation by Intestinal Epithelial Cells is the first book to bring together experimental evidence and discussion on the pathophysiological relevance of epithelial cells in intestinal immune defense mechanisms.

Audience: clinical specialists, researchers and medical students in molecular and cell biology

Medical Intelligence Unit series

R. G. Landes Company
March 1996 : 6 x 9 : approx.200pp
40 figures
Hardback: 0-412-10411-3: $79.95


Edited by Rifat Latifi, Yale University School of Medicine, New Haven, Connecticut

As we approach the end of the millennium, nutritional and metabolic support of surgical patients is entering a new era of development and clinical practice. Preventing profound metabolic alterations initiated by surgical disease with timely nutritional and metabolic support, or correcting them when present, has become an imperative and essential component of general medical and surgical care. Current Surgical Nutrition represents contemporary opinion in assessment of nutritional status and use of specific nutrients and formulations in the treatment of different conditions. It explores new horizons in surgical nutrition; nearly all chapters go beyond mere review and summary of the literature. Topics include: *biochemical assessment and monitoring of nutritional status *radiologic assessment of nutritional and metabolic status *current concepts and indications of total parenteral nutrition (TPN)*administration and monitoring of TPN *indications, delivery and complications of enteral nutrition *laparoscopic placement of enteral feeding tubes *nutrient substrates, particularly amino acids and lipids *protein metabolism in the liver and intestine during sepsis *nutritional management of short bowel syndrome *nutritional and metabolic implications of intestinal adaptation *intestingal regeneration *pharmacologic aspect of the short bowel disease *nutritional support in inflammatory bowel disease, acute pancreatitis and chronic liver failure* effect of parenteral nutrition on bone and mineral homeostasis *home parenteral nutrition in patients with gastrointestinal tract failure *computer assistance in nutrition support

Audience: clinicians, researchers and doctors in metabolism, nutrition and surgery

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.367pp
23 figures, 43 tables
Hardback: 0-412-10181-5: $79.95


W.R. Miller, Western General Hospital, University of Edinburgh

Breast cancer is the most common female malignancy and the most common cause of death in women ages 35 to 55; it will affect one in 12 women in the USA and Europe. This book reviews the evidence that estrogens are a major influence of risk to and growth of breast cancer. Featuring information from a diverse range of disciplines, Estrogen and Breast Cancer indicates how the breast and its tumors may obtain estrogen from different sources and display distinctive patterns and levels of estrogen. In addition, it illustrates how increasing knowledge of the mechanism of estrogen action is leading to new strategies, not only for women with breast cancer but also for those at high risk for the disease.

Audience: clinical specialists, general clinicians, researchers, residents, medical students, nurses and allied health personnel in cell biology, clinical oncology, reproductive biology and endocrinology.

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.207pp
53 figures, 22 tables
Hardback: 0-412-10371-0: $79.95


Examining the role of eicosanoids and procoagulants

Edited by John G. Williams, University of Texas Southwestern, Dallas, Texas

This volume summarizes recent developments in eicosanoid and procoagulant research, emphasizing the impact of new findings on understanding of multiple organ failure. This integrated approach consolidates recent eicosanoid and procoagulant research, provides an up-to-date conceptual framework in which to view inflammatory organ injury and suggests future avenues for investigation. Contents are organized to allow the reader to select particular topics of interest, including: * current concepts of normal inflammation, systemic inflammation and inflammatory organ injury * cell-associated procoagulant activity and its role in normal and dysfunctional inflammatory responses * eicosanoid regulation of procoagulant activity * inflammatory mediators in the pathogenesis of sepsis and organ failure * gut-derived eicosanoids in systemic inflammation and distant organ injury * recent research involving eicosanoids derived from vascular endothelium and their impact on inflammatory responses

Audience: clinical specialists, general clinicians, researchers and residents in molecular biology and cell biology

Medical Intelligence Unit series

R. G. Landes Company
March 1996 : 6 x 9 : approx.158pp
9 figures, 2 tables
Hardback: 0-412-10301-X: $79.95


Edited by Cherry L. Wainwright, University of Strathclyde, Glasgow and James R. Parratt, University of Strathclyde, Glasgow

Myocardial Preconditioning explores the unique ability of the heart to protect itself against the serious consequences of an abrupt reduction in blood flow to an area of the myocardium: a phenomenon initiated by an intal stress and termed myocardial preconditioning. Chapters describe the main features and characteristics of preconditioning, with respect to the time-course of the protective effect of the phenomenon and the different sequelae of myocardial ischaemia against which it protects (such as myocardial injury, arrhythmias and contractile dysfunction). Up-to-date discussions cover the proposed mechanisms underlying this form of cardioprotection, including the role of endogenous labile mediators, receptor-linked G proteins, ATP-sensitive potassium channels and protein kinase C activation. This book also considers the potential of the application of preconditioning to humans.

Audience: clinical specialists and researchers in cardiology

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.266pp
62 figures, 9 tables
Hardback: 0-412-10401-6: $79.95


Clague P. Hodgson, Creighton University

Retrovectors are the gene transfer systems used in 80% of ongoing clinical trials of gene therapy. Retroviruses and cellular retroelements are natural gene transfer materials that have been involved in the dispersal and regulation of genes throughout evolutionary history. The retroelements naturally comprise more than a quarter of the DNA in the human genome, and they are now being adapted for an important role in gene therapy. Retrovectors for Human Gene Therapy discusses conventional retroviruses and vector helper systems, as well as more recently developed retrotransposon and synthetic retrovectors.

Audience: clinical specialists and researchers in genetics

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.122pp
29 figures, 8 tables
Hardback: 0-412-10241-2: $79.95


Robert G. Gosden, University of Leeds and Yves Aubard, Centre Hospitalier Regional et Universitaire, France

This book covers the transplantation of ovaries or testes as whole organs or isolated cells, either for conserving fertility (autografts) or for overcoming a pre-existing state of sterility (allografts). Since the first transplant nearly a century ago, this technique has been instrumental in the investigation of reproductive physiology in experimental animals; now it is promising for patients whose fertile potential is threatened by gonadal disease or cancer treatment. Transplantation of Ovarian and Testicular Tissues is the first modern treatment of this subject: ideal both as a text for medical students and a reference for practitioners.

Audience: practitioners and students in the study of reproductive medicine and science

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.158pp
20 illus, 21 tables
Hardback: 0-412-10531-4: $79.95


Edited by Ian G. McFarlane, King's College Hospital, London and Roger Williams, King's College Hospital, London

During the past two decades, significant advances have been made in understanding the pathogenetic mechanisms. Recent improvements in diagnostic techniques have made it possible to refine criterial for diagnosis and to select more homogeneous populations of patients for study. At the same time, rapid advances in molecular biology are being applied to the study of autoimmune hepatitis and have accelerated understanding of the mechanisms underlying the development of the disease, its progression and its treatment. While the few previous books on the subject have concentrated on clinical features and management of the disease, this volume draws together recent data on: * the molecular aspects of the target antigens of cellular and humoral autoreactions, * the immunogenetics and other factors relating to susceptibility to the disease, * the mechanisms of liver damage with particular reference to information gleaned from studies in animal models, and * the molecular basis of treatment.

Audience: clinical specialists and researchers in molecular biology, cell biology, immunology, infectious disease and genetics

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.197pp
28 figures, 18 tables
Hardback: 0-412-10421-0: $69.95


Edited by J. Wesley Alexander, College of Medicine, University of Cincinnati and Robert A. Good, All Children's Hospital, St. Petersburg, Florida

This book defines current understanding of central (thymic) and peripheral (non-thymic) immunologic tolerance, including analysis of methods of production and mechanisms of apoptotic cell death and immunologic energy. Chapters consider the nature of immunodeviation and its relation to immunologic tolerance, as well as the nature of neonatal tolerance to tolerance produced later in life. Topics include: immunologic ignorance, immunologic tolerance, immunologic activation, immunologic responses, lymphoid cell proliferation and ultimate apoptopic destruction of lymphoid cells.

Audience: clinical specialists, researchers and residents in molecular biology, cell biology, immunology, transplantation, signal transduction physiology, vascular biology and cardiology

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.275pp
38 figures, 42 tables
Hardback: 0-412-10161-0: $79.95


Molecular Mechanisms of Septic Cardiomyopathy Edited by Ursula Muller-Werdan, Department of Medicine, University of Munich, Klinikum Grosshadern; Christopher Reithmann, Department of Medicine, University of Munich, Klinikum Grosshadern and Karl Werdan, Department of Mecicine, University of Munich, Klinikum Grosshadern

This book details the molecular mechanisms underlying septic cardiomyopathy, a main feature of septic shock and multiple organ dysfunction syndrome, which are the leading causes of death in intensive care patients. Cytokines play a very prominent pathogenetic role in this myocardial depression; Cytokines and the Heart covers topics including: * septic cardiomyopathy * researching mechanisms in septic cardiomyopathy * negative inotropic cascades" in cardiomyocytes triggered by substances relevant to sepsis * derangement of cardiac structure * derangement of coronary circulation * derangement of myocardial metabolism * derangement of inotropic axes of the cardiomyocyte * cytokines in non-septic heart diseases * toward a more casual treatment of septic cardiomyopathy * hypothetical and proven mechanisms of septic cardiomyopathy

Audience: clinical specialists, researchers and residents in virology, cell biology, signal transduction, intensive care medicine, physiology, infectious disease, cardiology, vascular disorders and cytokines

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.231pp
69 figures, 20 tables
Hardback: 0-412-10111-4: $79.95


Edited by Charles Orosz, Ohio State University College of Medicine; D. Sedmak, OSU School of Medicine and R. Ferguson, OSU School of Medicine

Transplant and Vascular Sclerosis is a compilation of state-of-the-art research on the pathobiology of transplant vascular sclerosis, one of the major causes of clinical graft loss. Featuring reviews by Plenary Session speakers at the recent meeting, this book covers:* graft vessel disease after heart transplantation,* chronic allograft arteriopathy, * chronic rejection in human allografts,* growth factors, cell signaling and the pathogenesis of atherosclerosis, * mediator molecules in chronic renal vascular rejection,L* immune-vascular interactions in atherosclerosis and transplant arteriosclerosis, * and much more.

Audience: clinical specialists and researchers in transplantation, immunology, cell biology and vascular pathology

Medical Intelligence Unit series

R. G. Landes Company
February 1996 : 6 x 9 : approx.222pp
28 figures, 9 tables
Hardback: 0-412-10121-1: $79.95

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