PRINCIPLES OF DRUG DEVELOPMENT IN TRANSPLANTATION AND
AUTOIMMUNITY
Edited by Ronald Lieberman, Food and Drug
Administration
Chronicles an ongoing revolution in immunology, biotechnology and
the emerging regulatory
science of drug development. Written by leading scientists from
academia, industry and
government, it encompasses pharmaceutical drug and biologic
development for transplantation
and autoimmunity. Topics include: * the molecular mechanisms of
recently approved
immunomodulators (tacrolimus, mycophenolate mofetil) * induction
of tolerance by
donor-specific cell therapy * oral antigenic tolerization to
genetically engineered cell transplants
for diabetes and parkinsonism * animal models * clinical
pharmacology * practical issues in trial
design and analysis * current status of promising new agents to
pharmacoeconomic principles of
drug marketing. This book is a guide for taking a new molecule
or recombinant DNA peptide
from concept, discovery and preclinical research to clinical
evaluation and postmarking
surveillance. The systematic approach delineated is relevant to
the development of new agents
for the treatment of disorders not involved with the immune
system.
Audience: researchers and clinicians in transplantation,
immunology, pharmacology and
therapeutics
A Chapman & Hall-R. G. Landes Co-Publication
February 1996 : 8-1/2 x 11 : approx.889pp
158 figures, 117 tables
Hardback: 0-412-10061-4: $99.95
MHC MOLECULES
Expression, Assembly and Function
Edited by Robert Urban, Harvard University, Boston,
Massachusetts and Roman M.
Chicz, Harvard University, Boston, Massachusetts
This book covers various gene products of the major
histocompatibility complex from
transcription to disease association and therapeutic regulation
of the cellular immune response.
Chapters are written by leading experts in the area of research,
and each includes a brief
introduction with additional references on the specifics of the
major histocompatibility complex.
Both experts in clinical immunology and newcomers to the field
will find this an invaluable
reference.
Audience: clinical specialists and researchers in
immunology, autoimmunity and
transplantation
A Chapman & Hall-R. G. Landes Co-Publication
February 1996 : 8-1/2 x 11 : approx.328pp
76 figures, 14 tables
Hardback: 0-412-10281-1: $79.95
REGULATION OF GENE EXPRESSION IN ESCHERIA COLI
Edited by Edmund C. Lin, Harvard Medical School, Boston,
Massachusetts and A. Simon Lynch, Harvard Medical School,
Boston, Massachusetts
This up-to-date guide focuses on the understanding of key
regulatory mechanisms governing
gene expression in Escherichia coli. Studies of E. coli not only
provided the first models of gene
regulation, but research continues to yield new and exciting
control mechanisms. Chapters are
contributed by researchers at the forefront of their respective
fields. As complete genomic DNA
sequences of bacteria become available, this volume will serve as
a useful guide to the
development of experimental strategies for those seeking to
explore aspects of gene regulation in
diverse bacterial species or to identify new antibiotic
targets.
Audience: researchers in genetics, gene regulation and
antibiotics, and
teachers/advanced students in the prokaryotic field
A Chapman & Hall-R. G. Landes Co-Publication
February 1996 : 6 x 9 : approx. 296pp
87 figures, 17 tables
Hardback: 0-412-10291-9: $79.95
HANDBOOK OF BONE MARROW TRANSPLANTATION
Edited by Richard K. Burt, Northwestern University Medical
School, Chicago, Illinois;
A therapeutic manual designed as a quick, practical guide and
reference for house oficers,
fellows and nurses on the bome marrow transplant unit..
Indications, complications, drug doeses
and approaches to clinical management problems are emphasized.
Diseases requiring bone
marrow transplants, such as multiple myeloma, lymphomas,
pediatric malignancies and adult
solid tumors have chapters devoted to them. This is the first
entry in the Chapman & Hall
Medical Consultant handbook series covering major medical
specialities.
Audience: specialists in bone marrow transplantation;
oncologists.
A Chapman & Hall-R. G. Landes Co-Publication
April 1996 : 6 x 9 : approx. 580pp
44 figures, 179 tables
Spiral bound: 0-412-10391-5: $49.95
Copyright 1996 Thomson Publishing All Rights Reserved